| Date | Location | Result | |
| Apr 20, 2022 | Muncie, IN | Ball St. 3, Lewis 0 (25-23,25-17,25-15) | Box score |
| Apr 16, 2022 | Romeoville, IL | Lewis 3, Ohio St. 2 (19-25,27-29,25-23,25-19,15-10) | Box score |
| Apr 09, 2022 | Romeoville, IL | Lewis 3, Lindenwood (MO) 1 (25-23,20-25,29-27,25-21) | Box score |
| Apr 07, 2022 | Romeoville, IL | Lewis 3, Quincy 1 (25-16,25-20,20-25,25-16) | Box score |
| Apr 02, 2022 | Muncie, IN | Ball St. 3, Lewis 0 (25-19,26-24,25-20) | Box score |
| Mar 31, 2022 | Columbus, OH | Lewis 3, Ohio St. 1 (26-24,17-25,25-23,25-18) | Box score |
| Mar 26, 2022 | Romeoville, IL | Loyola Chicago 3, Lewis 0 (25-18,25-17,26-24) | Box score |
| Mar 24, 2022 | Fort Wayne, IN | Lewis 3, Purdue Fort Wayne 0 (25-23,25-19,25-21) | Box score |
| Mar 19, 2022 | Lebanon, IL | McKendree 3, Lewis 2 (19-25,25-22,22-25,25-11,15-13) | Box score |
| Mar 17, 2022 | Romeoville, IL | Lewis 3, McKendree 1 (24-26,45-43,25-16,25-15) | Box score |
| Mar 12, 2022 | Honolulu, HI | Hawaii 3, Lewis 1 (25-18,27-29,25-19,26-24) | Box score |
| Mar 10, 2022 | Honolulu, HI | Hawaii 3, Lewis 0 (25-15,25-21,25-19) | Box score |
| Mar 04, 2022 | Romeoville, IL | Lewis 3, Emmanuel (GA) 0 (25-18,25-13,25-22) | Box score |
| Mar 02, 2022 | Romeoville, IL | Lewis 3, Benedictine (IL) 0 (25-21,25-20,25-20) | Box score |
| Feb 26, 2022 | Chicago, IL | Loyola Chicago 3, Lewis 0 (25-18,25-22,25-22) | Box score |
| Feb 24, 2022 | Romeoville, IL | Purdue Fort Wayne 3, Lewis 0 (25-23,25-23,25-22) | Box score |
| Feb 19, 2022 | Quincy, IL | Lewis 3, Quincy 0 (25-18,25-22,25-19) | Box score |
| Feb 18, 2022 | St. Charles, MO | Lindenwood (MO) 3, Lewis 2 (18-25,25-19,29-27,19-24,15-9) | Box score |
| Feb 12, 2022 | Romeoville, IL | Lewis 3, Ohio St. 1 (25-21,16-25,28-26,25-22) | Box score |
| Feb 10, 2022 | Romeoville, IL | Ball St. 3, Lewis 0 (31-29,25-22,25-20) | Box score |
| Feb 05, 2022 | Romeoville, IL | LEWIS 3, Grand Canyon 2 (26-24,19-25,25-23,20-25,15-10) | Box score |
| Jan 29, 2022 | Los Angeles, CA | LEWIS 3, UCLA 0 (25-21,25-20,25-23) | Box score |
| Jan 28, 2022 | Malibu, CA | Pepperdine 3, LEWIS 0 (25-19,25-20,25-21) | Box score |
| Jan 22, 2022 | Romeoville, IL | LEWIS 3, Belmont Abbey 0 (25-17,25-15,25-19) | Box score |
| Jan 21, 2022 | Romeoville, IL | Long Beach St. 3, LEWIS 1 (25-22,25-22,24-26,25-20) | Box score |
| Jan 15, 2022 | Romeoville, IL | LEWIS 3, Saint Francis (PA) 0 (25-20,29-27,25-18) | Box score |
| Jan 14, 2022 | Romeoville, IL | LEWIS 3, NJIT 1 (25-20,18-25,25-17,25-13) | Box score |
| Jan 11, 2022 | Romeoville, IL | LEWIS 3, Maryville (MO) 0 (25-13,25-11,25-12) | Box score |