| Date | Location | Result | |
| 03/06/22 | Edwardsville, IL (First Community Arena) | Drury 76, Lewis 47 | Box score |
| 03/05/22 | Edwardsville, IL (First Community Arena) | Lewis 88, Southern Ind. 72 | Box score |
| 03/04/22 | Edwardsville, IL (First Community Arena) | Lewis 83, Truman St. 75 | Box score |
| 02/28/22 | Romeoville, IL (Neil Carey Arena) | Lewis 74, Maryville (MO) 62 | Box score |
| 02/26/22 | Rolla, MO (Gibson Arena) | Missouri S&T 72, Lewis 67 (OT) | Box score |
| 02/24/22 | St. Louis, MO (Moloney Arena) | Maryville (MO) 67, Lewis 60 | Box score |
| 02/21/22 | Romeoville, IL (Neil Carey Arena) | Lewis 85, McKendree 74 | Box score |
| 02/19/22 | Romeoville, IL (Neil Carey Arena) | Lewis 66, Southwest Baptist 64 | Box score |
| 02/17/22 | Romeoville, IL (Neil Carey Arena) | Lewis 87, Drury 79 | Box score |
| 02/15/22 | Romeoville, IL (Neil Carey Arena) | Lewis 70, Mo.-St. Louis 60 | Box score |
| 02/12/22 | Liberty, MO (Mabee Center) | Lewis 84, William Jewell 50 | Box score |
| 02/10/22 | Kansas City, MO (M-H Fieldhouse) | Lewis 76, Rockhurst 68 | Box score |
| 02/07/22 | Romeoville, IL (Neil Carey Arena) | Lewis 72, Ill. Springfield 60 | Box score |
| 02/05/22 | Romeoville, IL (Neil Carey Arena) | Lewis 57, Quincy 55 | Box score |
| 02/03/22 | Romeoville, IL (Neil Carey Arena) | Truman 74, Lewis 61 | Box score |
| 01/27/22 | Springfield, IL (TRAC) | Ill. Springfield 76, Lewis 75 | Box score |
| 01/22/22 | Evansville, IN (Screaming Eagle Arena) | Lewis 72, Southern Indiana 63 | Box score |
| 01/20/22 | Indianapolis, IN (Nicoson Hall) | UIndy 69, Lewis 56 | Box score |
| 01/17/22 | Romeoville, IL (Neil Carey Arena) | Lewis 73, Lindenwood (MO) 68 | Box score |
| 01/08/22 | Springfield, MO (O'Reilly Events Center) | Drury 75, Lewis 61 | Box score |
| 01/06/22 | Kirksville, MO (Pershing Arena) | Truman 83, Lewis 75 | Box score |
| 12/20/21 | Romeoville, IL (Neil Carey Arena) | Grand Valley St. 65, Lewis 60 | Box score |
| 12/7/21 | Joliet, IL (Sullivan Center) | LEWIS 68, St. Francis (Ill.) 61 | Box score |
| 12/04/21 | Lebanon, IL (Harry Statham Court) | LEWIS 69, McKendree 50 | Box score |
| 12/02/21 | Romeoville, IL (Neil Carey Arena) | UIndy 79, LEWIS 67 | Box score |
| 11/27/21 | Romeoville, IL | Wis.-Parkside 80, LEWIS 79 | Box score |
| 11/23/21 | Romeoville, IL (Neil Carey Arena) | LEWIS 78, Purdue Northwest 57 | Box score |
| 11/20/21 | Romeoville, IL (Neil Carey Arena) | Ashland 80, LEWIS 79 | Box score |
| 11/17/21 | Romeoville, IL (Neil Carey Arena) | Ferris St. 85, LEWIS 77 | Box score |
| 11/14/21 | Marquette, MI (Berry Events Center) | Northern Mich. 61, LEWIS 56 | Box score |
| 11/13/21 | Marquette, MI (Berry Events Center) | Michigan Tech 75, LEWIS 71 | Box score |