| Date | Location | Result | |
| 03/03/21 | Romeoville, IL (Neil Carey Arena) | Mo.-St. Louis 69, Lewis 67 | Box score |
| 02/27/21 | Romeoville, IL (Neil Carey Arena) | Lewis 90, Maryville (MO) 77 | Box score |
| 02/25/21 | Romeoville, IL (Neil Carey Arena) | Lewis 93, Missouri S&T 71 | Box score |
| 02/20/21 | Springfield, MO (ORFC) | Drury 100, Lewis 57 | Box score |
| 02/18/21 | Bolivar, MO (Meyer Wellness Center) | Lewis 85, Southwest Baptist 60 | Box score |
| 02/11/21 | Romeoville, IL (Neil Carey Arena) | William Jewell 95, Lewis 77 | Box score |
| 02/08/21 | Kansas City, MO (Mason-Halpin FH) | Lewis 75, Rockhurst 55 | Box score |
| 02/06/21 | Kirksville, MO (Pershing Arena) | Truman 83, Lewis 74 | Box score |
| 01/26/21 | Saint Charles, MO (Hyland Arena) | Lewis 72, Lindenwood (MO) 67 | Box score |
| 01/21/21 | Romeoville, IL (Neil Carey Arena) | Southern Ind. 64, Lewis 59 | Box score |
| 01/16/21 | Romeoville, IL (Neil Carey Arena) | Lewis 73, UIndy 64 | Box score |
| 01/14/21 | Romeoville, IL (Neil Carey Arena) | Ill. Springfield 63, Lewis 62 | Box score |
| 01/12/21 | Springfield, IL (TRAC) | Lewis 78, Ill. Springfield 73 | Box score |
| 01/09/21 | Lebanon, IL (Harry M. Statham Court) | Lewis 77, McKendree 65 | Box score |
| 01/07/21 | St. Louis, MO (Moloney Arena) | Lewis 80, Maryville (MO) 65 | Box score |
| 01/05/21 | Romeoville, IL (Neil Carey Arena) | Lewis 87, Mo.-St. Louis 85 | Box score |
| 12/18/20 | Romeoville, IL (Neil Carey Arena) | McKendree 67, Lewis 54 | Box score |
| 12/12/20 | Quincy, IL (Pepsi Arena) | Lewis 68, Quincy 63 | Box score |
| 12/05/20 | Evansville, IN (Screaming Eagles Arena) | Southern Ind. 63, Lewis 52 | Box score |
| 12/03/20 | Indianapolis, IN (Nicoson Hall) | Lewis 80, UIndy 74 | Box score |
| 11/29/20 | Romeoville, IL (Neil Carey Arena) | Lewis 80, Quincy 70 | Box score |
| 11/27/20 | Romeoville, IL (Neil Carey Arena) | Truman 76, Lewis 66 | Box score |