| Date | Location | Result | |
| 03/05/22 | Edwardsville, IL (First Community Arena) | UIndy 72, Lewis 63 | Box score |
| 03/03/22 | Edwardsville, IL (First Community Arena) | Lewis 68, McKendree 58 | Box score |
| 02/28/22 | Romeoville, IL (Neil Carey Arena) | Lewis 69, Maryville (MO) 61 | Box score |
| 02/26/22 | Rolla, MO (Gibson Arena) | Missouri S&T 80, Lewis 61 | Box score |
| 02/24/22 | St. Louis, MO (Moloney Arena) | Maryville (MO) 49, Lewis 48 | Box score |
| 02/21/22 | Romeoville, IL (Neil Carey Arena) | Lewis 70, McKendree 62 | Box score |
| 02/19/22 | Romeoville, IL (Neil Carey Arena) | Lewis 89, Southwest Baptist 79 | Box score |
| 02/17/22 | Romeoville, IL (Neil Carey Arena) | Lewis 78, Drury 72 | Box score |
| 02/12/22 | Liberty, MO (Mabee Center) | William Jewell 65, Lewis 57 | Box score |
| 02/10/22 | Kansas City, MO (M-H Fieldhouse) | Lewis 73, Rockhurst 63 | Box score |
| 02/07/22 | Romeoville, IL (Neil Carey Arena) | Lewis 71, Ill. Springfield 63 | Box score |
| 02/05/22 | Romeoville, IL (Neil Carey Arena) | Lewis 83, Quincy 73 | Box score |
| 02/03/22 | Romeoville, IL (Neil Carey Arena) | Truman 89, Lewis 76 | Box score |
| 01/31/22 | Kirksville, MO (Pershing Arena) | Lewis 65, Truman 56 | Box score |
| 01/27/22 | Springfield, IL (TRAC) | Lewis 83, Ill. Springfield 63 | Box score |
| 01/22/22 | Evansville, IN (Screaming Eagle Arena) | Southern Indiana 67, Lewis 57 | Box score |
| 01/20/22 | Indianapolis, IN (Nicoson Hall) | Lewis 70, UIndy 69 | Box score |
| 01/17/22 | Romeoville, IL (Neil Carey Arena) | Lewis 76, Lindenwood (MO) 68 | Box score |
| 12/20/21 | Romeoville, IL (Neil Carey Arena) | Lewis 90, Ferris St. 85 | Box score |
| 12/16/21 | Romeoville, IL (Neil Carey Arena) | Lewis 82, St. Francis (IL) 45 | Box score |
| 12/04/21 | Lebanon, IL (Harry Statham Court) | Lewis 78, McKendree 62 | Box score |
| 12/02/21 | Romeoville, IL (Neil Carey Arena) | Lewis 85, UIndy 71 | Box score |
| 11/27/21 | Sault Ste. Marie, MI | Lake Superior St. 88, Lewis 67 | Box score |
| 11/23/21 | Hillsdale, MI (Tibbetts Porter Arena) | Hillsdale 67, Lewis 52 | Box score |
| 11/17/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne St. (MI) 68, Lewis 66 | Box score |
| 11/13/21 | Romeoville, IL (Neil Carey Arena) | Michigan Tech 64, Lewis 56 | Box score |
| 11/12/21 | Romeoville, IL (Neil Carey Arena) | Northern Mich. 67, Lewis 57 | Box score |