| Date | Location | Result | |
| 03/13/21 | Evansville, IN (Ford Center) | Southern Ind. 62, Lewis 60 | Box score |
| 03/07/21 | St. Louis, MO (Chuck Smith Court) | Lewis 76, Drury 71 | Box score |
| 03/06/21 | St. Louis, MO (Mark Twain Building) | Lewis 73, UIndy 57 | Box score |
| 03/03/21 | Lebanon, IL (Statham Sports Center) | Lewis 62, McKendree 59 | Box score |
| 02/27/21 | Romeoville, IL (Neil Carey Arena) | Lewis 81, Maryville (MO) 58 | Box score |
| 02/25/21 | Romeoville, IL (Neil Carey Arena) | Lewis 74, Missouri S&T 64 | Box score |
| 02/18/21 | Bolivar, MO (Meyer Wellness Center) | Southwest Baptist 64, Lewis 63 | Box score |
| 02/13/21 | Romeoville, IL (Neil Carey Arena) | Lewis 79, Rockhurst 66 | Box score |
| 02/11/21 | Romeoville, IL (Neil Carey Arena) | Lewis 75, William Jewell 66 | Box score |
| 02/06/21 | Kirksville, MO (Pershing Arena) | Truman 73, Lewis 66 | Box score |
| 02/04/21 | Quincy, IL (Pepsi Arena) | Lewis 94, Quincy 75 | Box score |
| 01/30/21 | Romeoville, IL (Neil Carey Arena) | Ill. Springfield 78, Lewis 75 (OT) | Box score |
| 01/23/21 | Romeoville, IL (Neil Carey Arena) | UIndy 78, Lewis 68 | Box score |
| 01/21/21 | Romeoville, IL (Neil Carey Arena) | Southern Ind. 74, Lewis 65 | Box score |
| 01/14/21 | Romeoville, IL (Neil Carey Arena) | Mo.-St. Louis 69, Lewis 64 | Box score |
| 01/12/21 | Springfield, IL (TRAC) | Ill. Springfield 69, Lewis 54 | Box score |
| 01/09/21 | Saint Charles, MO (Hyland Arena) | Lewis 80, Lindenwood (MO) 74 | Box score |
| 01/07/21 | St. Louis, MO (Moloney Arena) | Lewis 67, Maryville (MO) 61 | Box score |
| 01/03/21 | Kansas City, MO (Mason-Halpin FH) | Lewis 73, Rockhurst 47 | Box score |
| 12/19/20 | Romeoville, IL (Neil Carey Arena) | McKendree 70, Lewis 52 | Box score |
| 12/18/20 | Romeoville, IL (Neil Carey Arena) | Lewis 78, McKendree 63 | Box score |
| 12/15/20 | Indianapolis, IN (Nicoson Hall) | Lewis 77, Indianapolis 64 | Box score |
| 11/29/20 | Romeoville, IL (Neil Carey Arena) | Lewis 77, Quincy 70 | Box score |
| 11/27/20 | Romeoville, IL (Neil Carey Arena) | Truman 86, Lewis 65 | Box score |