| Date | Location | Result | |
| Dec 02, 2021 | Big Rapids, MI | Missouri-St. Louis 3, LEWIS 2 (21-25,29-27,29-27,22-25,15-13) | Box score |
| Nov 21, 2021 | East Peoria, IL | LEWIS 3, Missouri-St. Louis 2 (25-17,18-25,20-25,25-23,15-11) | Box score |
| Nov 20, 2021 | East Peoria, IL | LEWIS 3, Quincy 0 (25-19,25-17,25-20) | Box score |
| Nov 19, 2021 | East Peoria, IL | LEWIS 3, UIndy 0 (25-21,25-20,25-18) | Box score |
| Nov 13, 2021 | Evansville, IN | LEWIS 3, Southern Ind. 1 (26-24,25-23,20-25,25-18) | Box score |
| Nov 12, 2021 | Lebanon, IL | LEWIS 3, McKendree 0 (25-20,25-11,25-22) | Box score |
| Nov 6, 2021 | St. Louis, MO | LEWIS 3, Missouri-St. Louis 1 (20-25,25-16,25-17,25-12) | Box score |
| Nov 5, 2021 | Kirksville, MO | LEWIS 3, Truman 0 (25-20,25-19,25-15) | Box score |
| Nov 2, 2021 | Springfield, IL | LEWIS 3, Ill. Springfield 1 (25-11,21-25,25-23,25-19) | Box score |
| Oct 30, 2021 | Romeoville, IL | LEWIS 3, Rockhurst 2 (25-19,25-18,21-25,26-28,15-9) | Box score |
| Oct 29, 2021 | Romeoville, IL | LEWIS 3, Southwest Baptist 0 (25-10,25-16,25-11) | Box score |
| Oct 23, 2021 | Romeoville, IL | LEWIS 3, UIndy 1 (26-28,25-21,25-15,25-18) | Box score |
| Oct 16, 2021 | Hammond, IN | LEWIS 3, Northwood 0 (25-15,26-24,25-19) | Box score |
| Oct 15, 2021 | Hammond, IN | Hillsdale 3, LEWIS 0 (25-22,25-12,25-19) | Box score |
| Oct 15, 2021 | Hammond, IN | Michigan Tech 3, LEWIS 0 (25-23,28-26,25-12) | Box score |
| Oct 9, 2021 | Rolla, MO | LEWIS 3, Missouri S&T 0 (25-14,25-22,25-13) | Box score |
| Oct 8, 2021 | Springfield, MO | Drury 3, LEWIS 2 (12-25,25-18,17-25,27-25,15-9) | Box score |
| Oct 5, 2021 | Romeoville, IL | LEWIS 3, Ill. Springfield 2 (18-25,25-21,22-25,25-12,15-12) | Box score |
| Oct 2, 2021 | Romeoville, IL | LEWIS 3, Lindenwood (MO) 0 (25-18,25-15,25-13) | Box score |
| Oct 1, 2021 | Romeoville, IL | LEWIS 3, Maryville 0 (25-13,25-17,25-17) | Box score |
| Sep 28, 2021 | Indianapolis, IN | LEWIS 3, UIndy 1 (19-25,25-20,30-28,25-18) | Box score |
| Sep 25, 2021 | Romeoville, IL | LEWIS 3, Southern Ind. 1 (25-11,23-25,25-13,25-15) | Box score |
| Sep 24, 2021 | Romeoville, IL | LEWIS 3, McKendree 0 (25-12,25-14,25-10) | Box score |
| Sep 18, 2021 | Liberty, MO | LEWIS 3, William Jewell 1 (25-16,24-26,25-19,25-13) | Box score |
| Sep 16, 2021 | Romeoville, IL | LEWIS 3, Quincy 0 (25-21,25-19,25-12) | Box score |
| Sep 11, 2021 | Denver, CO | Central Missouri 3, LEWIS 2 (23-25,25-14,25-21,22-25,15-5) | Box score |
| Sep 11, 2021 | Denver, CO | Regis (CO) 3, LEWIS 1 (25-20,25-21,22-25,27-25) | Box score |
| Sep 10, 2021 | Denver, CO | LEWIS 3, Western Washington 0 (25-16,26-24,25-16) | Box score |
| Sep 10, 2021 | Denver, CO | Wayne St. (NE) 3, LEWIS 0 (25-20,25-14,25-23) | Box score |
| Sep 04, 2021 | St. Augustine, FL | LEWIS 3, Valdosta St. 1 (25-11,25-15,16-25,25-21) | Box score |
| Sep 04, 2021 | St. Augustine, FL | LEWIS 3, Belmont Abbey 0 (25-12,25-13,25-15) | Box score |
| Sep 03, 2021 | St. Augustine, FL | LEWIS 3, Flagler 1 (25-20,28-30,25-16,25-15) | Box score |
| Sep 03, 2021 | St. Augustine, FL | LEWIS 3, Eckerd 0 (25-16,25-15,25-7) | Box score |