| Date | Location | Result | |
| Nov 7, 2021 | Springfield, MO | Drury 2, LEWIS 0 | Box score |
| Oct 31, 2021 | Rolla, MO | Missouri S&T 1, LEWIS 0 | Box score |
| Oct 29, 2021 | St. Louis, MO | Maryville (MO) 3, LEWIS 2 (OT) | Box score |
| Oct 24, 2021 | Romeoville, IL | LEWIS 4, Southwest Baptist 2 | Box score |
| Oct 22, 2021 | Romeoville, IL | LEWIS 1, Drury 0 | Box score |
| Oct 17, 2021 | Liberty, MO | LEWIS 5, William Jewell 2 | Box score |
| Oct 15, 2021 | Kansas City, MO | LEWIS 2, Rockhurst 0 | Box score |
| Oct 10, 2021 | Romeoville, IL | Quincy 1, LEWIS 0 | Box score |
| Oct 8, 2021 | Romeoville, IL | Truman 1, LEWIS 0 | Box score |
| Oct 1, 2021 | Springfield, IL | LEWIS 1, Ill.-Springfield 0 | Box score |
| Sep 26, 2021 | Evansville, IN | LEWIS 0, Southern Indiana 0 (2OT) | Box score |
| Sep 24, 2021 | Indianapolis, IN | Indianapolis 2, LEWIS 1 | Box score |
| Sep 19, 2021 | Romeoville, IL | LEWIS 1, Mo.-St. Louis 0 | Box score |
| Sep 17, 2021 | Romeoville, IL | McKendree 0, LEWIS 0 (2OT) | Box score |
| Sep 12, 2021 | Romeoville, IL | LEWIS 1, Lindenwood 0 | Box score |
| Sep 04, 2021 | Hammond, IN | LEWIS 3, Purdue Northwest 2 | Box score |
| Sep 02, 2021 | Romeoville, IL | LEWIS 2, Tiffin 1 (OT) | Box score |